Aivia Neuro
Ultrafast Automatic 3D Neuron Reconstruction

What You Get

The backbone of all Aivia packages. It features high performance volume and surface rendering engines capable of handling even the most demanding (multi-terabyte, multi-channel time series) microscopy datasets. It offers a wide range of visualization models which enables you to explore your data. Basic quantitative options such as Measurement, Spreadsheet, Charts and Annotations are also included with Aivia Base.

Aivia Base

You can train a machine learning model to distinguish objects of interest from background. The Pixel Classifier provides a powerful way to detect objects in images where conventional threshold-based methods are not enough.

Machine Learning Pixel Classifier

The 3D Neuron Analysis recipe in Aivia detects and automatically traces dendrites in fluorescent 3D volumetric images. The recipe has options for tracing dendrites with or without soma, as well as options for automatic detection of dendritic spines. After applying the recipe, you can extend the analysis by applying the pre-trained neuron classifier to classify the detected neurons.

3D Neuron Analysis

The Neuron Composer allows you to edit detected neuron analysis results or manually trace neurons on a 3D image. You can trace dendrites using Predict Segment tool and add spines to your analysis results with one-click using the Spine Editor tool. You can also edit the dendritic arbor by removing incorrect network connections on the image and re-connect to the correct segment.

Neuron Editing
 

The Aivia Neuro package is designed for neuroscientists looking for an automated neuron tracing and spine analysis solution. The package includes Aivia's ultrafast neuron analysis recipe that generates full neuron reconstruction of an image in seconds. You can extend your analysis further with optional spine detection with the recipe. In addition, Aivia Neuro also provides intuitive computer assisted neuron tracing tools to help you edit the automated analysis output or create your own reconstruction.

 

 

Features at-a-glance
  • Display and work with huge (100s of GBs) datasets
  • Ultrafast neuron tracing generating complete reconstructions in seconds
  • Detect dendritic spines
  • Access a wide range of morphology, intensity and neuron measurements
  • Intuitive neuron editing tools for manual reconstructions
  • Three (3) years of technical support plus software updates included
 
 
 
 

Measurements

Aivia's image analysis solutions automatically calculate many measurements for all detected objects as well as statistics about the entire population. You can explore the data further using the built-in Charts in Aivia and classify objects of interest using our machine learning object classifier tool.

Here are some common measurements that Aivia provides:

Neuron
  • Dendrite Count

  • Surface Area

  • Volume

  • Intensity

Dendrite
  • Total Branch Length

  • Branch Count

  • Spine Count

  • Branch Generation

Spine
  • Volume

  • Head Diameter

  • Length to Head Diameter Ratio

  • Branch Angle

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