3D Object Tracking and Lineage Tracing
Capturing the motion of life
Detecting, analyzing and understanding how cells, organelles and particles move in 3D environments is essential for a wide range of research fields. Moreover, normal cell division and cell differentiation are both critical to the development and homeostasis of most biological systems including humans. Abnormal cell division and uncontrolled cell differentiation are critical factors in a variety of conditions including cancer, immunological disorders and developmental defects.
Aivia 7 introduces a state-of-the-art 3D object tracking approach which builds on the 3D object detection recipe launched in Aivia 6 and seamlessly blends the advantages of motion and intensity based object tracking. See our ASCB|EMBO 2017 poster describing underlying technology here.
In addition, Aivia 7 automatically traces cell lineages and displays them in the 3D View and in two plot types (Lineage and Flow plot). Both plots are synchronized with the 3D View, the Track Editor (see below) as well as the Spreadsheet thus allowing the user to easy inspection of the results, determine their accuracy as well as relevance.
3D object tracking
3D lineage tracing and fate analysis
Dual score tracking algorithm (Motion vs Intensity)
Wide range of track display options
Motion and lineage specific measurements
Supports large data sets (tens of GB per time point, over 1TB per experiment)
After tracking the user has a myriad of track display options which include independent controls for tracks, anchors (i.e. the track points), trends (i.e. the vectors that indicate overall direction for each track). Each display option has its own size/scale and color controls to ensure you can get the perfect visualization output for your presentations and publications.
Note: Aivia introduced 2D object tracking and lineage tracing in 2013
Track and Lineage Editing
As easy as drag-and-drop
Connect and disconnect tracks
Use Workspaces to conveniently edit groups of tracks
Create and edit lineages
Multiple and easy track selection options
Review edits in real time
Synchronization between data view, Track Editor, Charts and Spreadsheet
Aivia 7 offers you a complete and highly intuitive Track Editor so you can build on the results automatically generated. This way you have the option to get to the perfect result by leveraging your trained eye.
The editor allows you to create multiple Workspaces where you can interact with and edit a subset of tracks/lineages without being distracted by all the items you are not interested in editing. Making an edit consists of a single click-drag-n-drop. Aivia will ask you what kind of edit you want to do before completing it. The edits automatically update the 3D View, the Spreadsheet, the Charts and all the Track Editor Workspaces. The track editor supports undo/redo - sometimes a big time saver.
Fast Surface Rendering
No more waiting - see your results now
Option 1: Standard surface rendering
Aivia 7 fast surface rendering
Multi GB data sets are routinely created by a wide range of microscopes. With Aivia 6.0 we introduced a revolutionary new way to interactively display super large data sets. Aivia 7.0 goes one step beyond allowing its users to explore many hundreds of thousands of objects of interest in real time. We have accomplished this by: a) drastically optimizing the data flow from the hard disk to the GPU, b) maximizing the reuse of points needed to generate a surface and c) intelligent data caching. Together, these items allow Aivia users to render and interact with hundreds of thousands of objects per time point. With Aivia 7.0 you will save up 98% of the time previously needed to render 3D surface objects!
"What if I don't have a multi GB file?" You will still benefit. For you Aivia will do nearly every operation in an instant.
Real time interaction with hundreds of thousands of objects per time point
Navigate instantaneously to any time point - intelligent caching
Optimized data flow (disk to GPU) and object generation
Real time multi-object selection and update of display properties
Option 1 - standard surface rendering
Option 2 - optimized / accelerated surface rendering. Only requires 68% of the time (vs Option 1) required to display surfaces
Aivia 7.0 - highly optimized data flow, reuse of data points and intelligent caching. It renders surfaces in 2% of the time versus Option 1.
Please fill in your contact details and tell us more about your research and image analysis requirements
15921 NE 8th St, Suite 200
Bellevue, WA 98008
Lossless compression and more
In addition to the major features above, Aivia 7 brings tens of new improvements to help make the overall Aivia experience better. Here are some of the improvements you will find in Aivia 7:
Aivia.tiff with lossless compression
Even faster Aivia.tiff for large (in the Z dimension) - efficient down sampling also in Z (previously only X and Y)
Color detected objects (outlines, surfaces, tracks, dendrites and spines) by any calculated measurement
More robust soma (neurons) detection and analysis
More accurate neuron tracing